FL-501

Anti-GDF-15 antibody image description

FL-501 antibody mechanism

FL-501 is a potential best in class antibody designed to neutralize GDF-15 and prevent the binding to its receptor. FL-501 was engineered for higher target affinity and a longer plasma half-life compared to competing therapies. In preclinical cachexia models, FL-501 increased body weight and restored muscle mass.

FL-501 may be expected to reverse immunosuppression in cancers where elevated GDF-15 is correlated with poor survival. FL-501 may also play a role in treating other GDF-15-related diseases.

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Immunostimulation in tumor microenvironment

Weight gain, normal appetite, improved muscle mass

Improved maternal health

Renoprotective effects

Pulmonary improvement

Cardioprotective effects